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If you have product questions about NEUPOGEN® and would like to speak with a Medical Information representative, please call us at 1-800-77-AMGEN.

If you have questions about patient assistance programs, visit the Amgen Assist® website or call 1-800-272-9376.

Click here for NEUPOGEN® product information.

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Important Safety Information

Do not take NEUPOGEN® if you have had a serious allergic reaction to human G-CSFs such as (filgrastim) or (pegfilgrastim) products.

Before you take NEUPOGEN®, tell your healthcare provider all about your medical conditions, including if you:

  • have a sickle cell disorder.
  • have kidney problems.
  • are receiving radiation therapy.
  • are allergic to latex. The needle cap on the prefilled syringe contains dry natural rubber (derived from latex). You should not give NEUPOGEN® using the prefilled syringe if you have latex allergies. Ask your healthcare provider about using the vial if you have latex allergies.
  • are pregnant, or plan to become pregnant. It is not known if NEUPOGEN® will harm your unborn baby.
  • are breastfeeding, or plan to breastfeed. It is not known if NEUPOGEN® passes into your breast milk.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

How will I receive NEUPOGEN®?

  • NEUPOGEN® injections can be given by a healthcare provider by intravenous (IV) infusion or under your skin (subcutaneous injection). Your healthcare provider may decide subcutaneous injections can be given at home by you or your caregiver. If NEUPOGEN® is given at home, see the detailed "Instructions for Use" that comes with your NEUPOGEN® for information on how to prepare and inject a dose of NEUPOGEN®.
  • You and your caregiver should be shown how to prepare and inject NEUPOGEN® before you use it, by your healthcare provider.
  • Your healthcare provider will tell you how much NEUPOGEN® to inject and when to inject it. Do not change your dose or stop NEUPOGEN® unless your healthcare provider tells you to.
  • If you are receiving NEUPOGEN® because you are also receiving chemotherapy, your dose of NEUPOGEN® should be injected at least 24 hours before or 24 hours after your dose of chemotherapy.

What are possible side effects of NEUPOGEN®?

  • Spleen rupture. Your spleen may become enlarged and can rupture. A ruptured spleen can cause death. Call your healthcare provider right away if you have pain in the left upper stomach area or left shoulder.
  • A serious lung problem called Acute Respiratory Distress Syndrome (ARDS). Call your healthcare provider or get emergency medical help right away if you have shortness of breath with or without a fever, trouble breathing, or a fast rate of breathing.
  • Serious allergic reactions. NEUPOGEN® can cause serious allergic reactions. These reactions can cause a rash over your whole body, shortness of breath, wheezing, dizziness, swelling around your mouth or eyes, fast heart rate, and sweating. If you have any of these symptoms, stop using NEUPOGEN®, and call your healthcare provider or get emergency help right away.
  • Sickle cell crises. You may have a serious sickle cell crisis if you have a sickle cell disorder and receive NEUPOGEN®. Serious sickle cell crises have happened in people with sickle cell disorders receiving NEUPOGEN® that has sometimes led to death. Call your healthcare provider right away if you have symptoms of sickle cell crisis such as pain or difficulty breathing.
  • Kidney injury (glomerulonephritis). NEUPOGEN® can cause kidney injury. Call your healthcare provider right away if you develop any of the following symptoms:
    • swelling of your face and ankles
    • blood in your urine or dark colored urine
    • you urinate less than usual
  • Capillary Leak Syndrome. NEUPOGEN® can cause fluid to leak from blood vessels into your body's tissues. This condition is called "Capillary Leak Syndrome" (CLS). CLS can quickly cause you to have symptoms that may become life-threatening. Get emergency medical help right away if you develop any of the following symptoms:
    • swelling or puffiness and are urinating less than usual
    • trouble breathing
    • swelling of your stomach-area and feeling of fullness
    • dizziness or feeling faint
    • a general feeling of tiredness
  • Decreased platelet count (thrombocytopenia). Your healthcare provider will check your blood during treatment with NEUPOGEN®. Tell your healthcare provider if you have unusual bleeding or bruising during treatment with NEUPOGEN®. This could be a sign of decreased platelet counts, which may reduce the ability of your blood to clot.
  • Increased white blood cell count (leukocytosis). Your healthcare provider will check your blood during treatment with NEUPOGEN®.
  • Inflammation of your blood vessels (cutaneous vasculitis). Tell your healthcare provider if you develop purple spots or redness of your skin.

The most common side effects of NEUPOGEN® include aching in the bones and muscles. These are not all the possible side effect of NEUPOGEN®. Call your healthcare provider for medical advice about side effects. You may report side effects to FDA at 1-800-332-1088.

Please see the NEUPOGEN® Patient Information for additional information.

The last dose of NEUPOGEN® (filgrastim) should be injected at least 24 hours before your next dose of chemotherapy. NEUPOGEN® should be injected at the same time each day. If you miss a dose, contact your doctor or nurse.

You must always use the correct dose of NEUPOGEN®. Too little may not protect you against infections, and too much may cause too many neutrophils to be in your blood. If you are giving someone else NEUPOGEN® injections, it is important that you know how to inject, how much to inject, and how often to inject.

For more information, please see the NEUPOGEN® Patient Product Information and talk to your doctor.

No use NEUPOGEN® durante las 24 horas anteriores ni las 24 horas posteriores a la administración de quimioterapia fuerte. NEUPOGEN® debe inyectarse a la misma hora todos los días. Si se salta una dosis, póngase en contacto con el médico o el enfermero.

Es indispensable que use siempre la dosis correcta de NEUPOGEN®. Una cantidad insuficiente quizás no ayude a reducir el riesgo de contraer infecciones, y un exceso podría generar demasiados neutrófilos en la sangre. Si usted le administra las inyecciones de NEUPOGEN® a otra persona, es importante que sepa cómo inyectar el medicamento, las dosis que debe inyectar y con qué frecuencia debe poner las inyecciones.

Para obtener más información sobre cómo preparar y administrar una inyección de NEUPOGEN® consulte la información del producto para los pacientes y la información de prescripción de NEUPOGEN®. Si tiene preguntas, deberá hablar con su médico.