Is NEUPOGEN® right
for me?

If you are on strong chemotherapy, it's important to ask your doctor if you are at risk for developing febrile neutropenia (neutropenia with fever), and how NEUPOGEN® helps reduce that risk. Talk to your doctor about other factors that may put you at risk.

Start the discussion with your doctor by viewing these questions

NEUPOGEN® is used to treat neutropenia, a condition where the body makes too few neutrophils. Neutrophils are a type of white blood cell important in the body's fight against infection.

NEUPOGEN® helps to reduce the risk of infection (marked by fever) in patients with certain types of cancer who are receiving strong chemotherapy that decreases the number of infection-fighting white blood cells. This type of infection is called febrile neutropenia (neutropenia with fever). Studies have shown that some people have a greater risk of a low white blood cell count or infection when treated with strong chemotherapy.

How does NEUPOGEN® work?

NEUPOGEN® helps boost the production of infection-fighting white blood cells called neutrophils

G-CSF and white blood cells
NEUPOGEN works like G-CSF
NEUTROPHILS reduce the risk of infection
G-CSF and white blood cells

The body makes G-CSF

The body makes a natural protein called G-CSF, which acts in the bone marrow to boost the production of white blood cells called neutrophils.

NEUPOGEN works like G-CSF

NEUPOGEN® is a form
of G-CSF

Like G-CSF, NEUPOGEN® acts in the bone marrow, where it helps boost the production of white blood cells.

NEUTROPHILS reduce the risk of infection

NEUTROPHILS may
mature faster

With NEUPOGEN®, white blood cells may mature faster into neutrophils, ready for release into the blood stream to help fight bacteria and help reduce the risk of infection.

NEUPOGEN® Study Results

NEUPOGEN® was shown to help boost the production of infection-fighting white blood cells called neutrophils

A key study of NEUPOGEN® involved 210 patients with small-cell lung cancer. These patients received up to 6 cycles of chemotherapy. There were 2 groups of patients.

  • One group of 99 patients received NEUPOGEN® every day for up to 14 days during every cycle (NEUPOGEN® treatment started approximately 24 hours after chemotherapy ended)
  • The other group of 111 patients did not receive NEUPOGEN® (they received placebo)

NEUPOGEN® reduced the risk of infection

Over the 6 cycles in this study, 76% of patients who did not take NEUPOGEN® developed neutropenia with fever compared to 40% of patients who did take NEUPOGEN®. This means NEUPOGEN® reduced the number of patients who developed neutropenia with fever by nearly half.

Patients treated with NEUPOGEN® had a

0%reduction in the incidence of febrile neutropenia

How is NEUPOGEN® taken?

Daily treatment with NEUPOGEN®

The needle cover on the single-use prefilled syringe contains dry natural rubber (latex), which should not be handled by persons sensitive to this substance.
NEUPOGEN® is available as a liquid in vials or in prefilled syringes.
NEUPOGEN® is taken as an injection

NEUPOGEN® is taken as an injection under the skin (called a subcutaneous injection) once daily during each cycle of chemotherapy. NEUPOGEN® may also be given by a healthcare provider as an intravenous (or IV) infusion.

  • Do not use NEUPOGEN® in the period 24 hours before through 24 hours after the administration of strong chemotherapy.

  • NEUPOGEN® should be injected at the same time each day

  • If you miss a dose of NEUPOGEN®, contact your doctor or nurse

  • You must always use the correct dose of NEUPOGEN®

    • Too little NEUPOGEN® may not help reduce your risk of infection

    • Too much NEUPOGEN® may cause too many neutrophils to be in your blood

  • If you are giving someone else NEUPOGEN® injections, it is important that you know how to inject NEUPOGEN®, how much to inject, and how often to inject NEUPOGEN

What is NEUPOGEN® used for?

NEUPOGEN® is approved for several uses to help boost the production of white blood cells

  • Patients with cancer receiving strong chemotherapy
  • NEUPOGEN® is a prescription medicine used to help reduce the chance of infection due to a low white blood cell count, in people with certain types of cancer (non‐myeloid) who receive anti‐cancer medicines (chemotherapy) that can cause fever and a low blood cell count.

    Important Safety Information

    Do not take NEUPOGEN® if you have had a serious allergic reaction to human G-CSFs such as (filgrastim) or (pegfilgrastim) products.

    Before you take NEUPOGEN®, tell your healthcare provider all about your medical conditions, including if you:

    • have a sickle cell disorder.
    • have kidney problems.
    • are receiving radiation therapy.
    • are allergic to latex. The needle cap on the prefilled syringe contains dry natural rubber (derived from latex). You should not give NEUPOGEN® using the prefilled syringe if you have latex allergies. Ask your healthcare provider about using the vial if you have latex allergies.
    • are pregnant, or plan to become pregnant. It is not known if NEUPOGEN® will harm your unborn baby.
    • are breastfeeding, or plan to breastfeed. It is not known if NEUPOGEN® passes into your breast milk.

    Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

    How will I receive NEUPOGEN®?

    • NEUPOGEN® injections can be given by a healthcare provider by intravenous (IV) infusion or under your skin (subcutaneous injection). Your healthcare provider may decide subcutaneous injections can be given at home by you or your caregiver. If NEUPOGEN® is given at home, see the detailed "Instructions for Use" that comes with your NEUPOGEN® for information on how to prepare and inject a dose of NEUPOGEN®.
    • You and your caregiver should be shown how to prepare and inject NEUPOGEN® before you use it, by your healthcare provider.
    • Your healthcare provider will tell you how much NEUPOGEN® to inject and when to inject it. Do not change your dose or stop NEUPOGEN® unless your healthcare provider tells you to.
    • If you are receiving NEUPOGEN® because you are also receiving chemotherapy, your dose of NEUPOGEN® should be injected at least 24 hours before or 24 hours after your dose of chemotherapy.

    What are possible side effects of NEUPOGEN®?

    • Spleen rupture. Your spleen may become enlarged and can rupture. A ruptured spleen can cause death. Call your healthcare provider right away if you have pain in the left upper stomach area or left shoulder.
    • A serious lung problem called Acute Respiratory Distress Syndrome (ARDS). Call your healthcare provider or get emergency medical help right away if you have shortness of breath with or without a fever, trouble breathing, or a fast rate of breathing.
    • Serious allergic reactions. NEUPOGEN® can cause serious allergic reactions. These reactions can cause a rash over your whole body, shortness of breath, wheezing, dizziness, swelling around your mouth or eyes, fast heart rate, and sweating. If you have any of these symptoms, stop using NEUPOGEN®, and call your healthcare provider or get emergency help right away.
    • Sickle cell crises. You may have a serious sickle cell crisis if you have a sickle cell disorder and receive NEUPOGEN®. Serious sickle cell crises have happened in people with sickle cell disorders receiving NEUPOGEN® that has sometimes led to death. Call your healthcare provider right away if you have symptoms of sickle cell crisis such as pain or difficulty breathing.
    • Kidney injury (glomerulonephritis). NEUPOGEN® can cause kidney injury. Call your healthcare provider right away if you develop any of the following symptoms:
      • swelling of your face and ankles
      • blood in your urine or dark colored urine
      • you urinate less than usual
    • Capillary Leak Syndrome. NEUPOGEN® can cause fluid to leak from blood vessels into your body's tissues. This condition is called "Capillary Leak Syndrome" (CLS). CLS can quickly cause you to have symptoms that may become life-threatening. Get emergency medical help right away if you develop any of the following symptoms:
      • swelling or puffiness and are urinating less than usual
      • trouble breathing
      • swelling of your stomach-area and feeling of fullness
      • dizziness or feeling faint
      • a general feeling of tiredness
    • Decreased platelet count (thrombocytopenia). Your healthcare provider will check your blood during treatment with NEUPOGEN®. Tell your healthcare provider if you have unusual bleeding or bruising during treatment with NEUPOGEN®. This could be a sign of decreased platelet counts, which may reduce the ability of your blood to clot.
    • Increased white blood cell count (leukocytosis). Your healthcare provider will check your blood during treatment with NEUPOGEN®.
    • Inflammation of your blood vessels (cutaneous vasculitis). Tell your healthcare provider if you develop purple spots or redness of your skin.

    The most common side effects of NEUPOGEN® include aching in the bones and muscles. These are not all the possible side effect of NEUPOGEN®. Call your healthcare provider for medical advice about side effects. You may report side effects to FDA at 1-800-332-1088.

    Please see the NEUPOGEN® Patient Information for additional information.

  • Patients with acute myeloid leukemia (AML) receiving chemotherapy
  • NEUPOGEN® is a prescription medicine used for reducing the duration of a low white blood cell count and fever, following chemotherapy in patients with acute myeloid leukemia (AML).

    Important Safety Information

    Do not take NEUPOGEN® if you have had a serious allergic reaction to human G-CSFs such as (filgrastim) or (pegfilgrastim) products.

    Before you take NEUPOGEN®, tell your healthcare provider all about your medical conditions, including if you:

    • have a sickle cell disorder.
    • have kidney problems.
    • are receiving radiation therapy.
    • are allergic to latex. The needle cap on the prefilled syringe contains dry natural rubber (derived from latex). You should not give NEUPOGEN® using the prefilled syringe if you have latex allergies. Ask your healthcare provider about using the vial if you have latex allergies.
    • are pregnant, or plan to become pregnant. It is not known if NEUPOGEN® will harm your unborn baby.
    • are breastfeeding, or plan to breastfeed. It is not known if NEUPOGEN® passes into your breast milk.

    Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

    How will I receive NEUPOGEN®?

    • NEUPOGEN® injections can be given by a healthcare provider by intravenous (IV) infusion or under your skin (subcutaneous injection). Your healthcare provider may decide subcutaneous injections can be given at home by you or your caregiver. If NEUPOGEN® is given at home, see the detailed "Instructions for Use" that comes with your NEUPOGEN® for information on how to prepare and inject a dose of NEUPOGEN®.
    • You and your caregiver should be shown how to prepare and inject NEUPOGEN® before you use it, by your healthcare provider.
    • Your healthcare provider will tell you how much NEUPOGEN® to inject and when to inject it. Do not change your dose or stop NEUPOGEN® unless your healthcare provider tells you to.
    • If you are receiving NEUPOGEN® because you are also receiving chemotherapy, your dose of NEUPOGEN® should be injected at least 24 hours before or 24 hours after your dose of chemotherapy.

    What are possible side effects of NEUPOGEN®?

    • Spleen rupture. Your spleen may become enlarged and can rupture. A ruptured spleen can cause death. Call your healthcare provider right away if you have pain in the left upper stomach area or left shoulder.
    • A serious lung problem called Acute Respiratory Distress Syndrome (ARDS). Call your healthcare provider or get emergency medical help right away if you have shortness of breath with or without a fever, trouble breathing, or a fast rate of breathing.
    • Serious allergic reactions. NEUPOGEN® can cause serious allergic reactions. These reactions can cause a rash over your whole body, shortness of breath, wheezing, dizziness, swelling around your mouth or eyes, fast heart rate, and sweating. If you have any of these symptoms, stop using NEUPOGEN®, and call your healthcare provider or get emergency help right away.
    • Sickle cell crises. You may have a serious sickle cell crisis if you have a sickle cell disorder and receive NEUPOGEN®. Serious sickle cell crises have happened in people with sickle cell disorders receiving NEUPOGEN® that has sometimes led to death. Call your healthcare provider right away if you have symptoms of sickle cell crisis such as pain or difficulty breathing.
    • Kidney injury (glomerulonephritis). NEUPOGEN® can cause kidney injury. Call your healthcare provider right away if you develop any of the following symptoms:
      • swelling of your face and ankles
      • blood in your urine or dark colored urine
      • you urinate less than usual
    • Capillary Leak Syndrome. NEUPOGEN® can cause fluid to leak from blood vessels into your body's tissues. This condition is called "Capillary Leak Syndrome" (CLS). CLS can quickly cause you to have symptoms that may become life-threatening. Get emergency medical help right away if you develop any of the following symptoms:
      • swelling or puffiness and are urinating less than usual
      • trouble breathing
      • swelling of your stomach-area and feeling of fullness
      • dizziness or feeling faint
      • a general feeling of tiredness
    • Decreased platelet count (thrombocytopenia). Your healthcare provider will check your blood during treatment with NEUPOGEN®. Tell your healthcare provider if you have unusual bleeding or bruising during treatment with NEUPOGEN®. This could be a sign of decreased platelet counts, which may reduce the ability of your blood to clot.
    • Increased white blood cell count (leukocytosis). Your healthcare provider will check your blood during treatment with NEUPOGEN®.
    • Inflammation of your blood vessels (cutaneous vasculitis). Tell your healthcare provider if you develop purple spots or redness of your skin.

    The most common side effects of NEUPOGEN® include aching in the bones and muscles. These are not all the possible side effect of NEUPOGEN®. Call your healthcare provider for medical advice about side effects. You may report side effects to FDA at 1-800-332-1088.

    Please see the NEUPOGEN® Patient Information for additional information.

  • Patients with cancer undergoing bone marrow transplantation (BMT)
  • NEUPOGEN® is a prescription medicine used to reduce the duration of low white blood cell count and its effects, such as increased risk of infection in people with certain types of cancer (nonmyeloid) receiving very strong chemotherapy followed by bone marrow transplant.

    Important Safety Information

    Do not take NEUPOGEN® if you have had a serious allergic reaction to human G-CSFs such as (filgrastim) or (pegfilgrastim) products.

    Before you take NEUPOGEN®, tell your healthcare provider all about your medical conditions, including if you:

    • have a sickle cell disorder.
    • have kidney problems.
    • are receiving radiation therapy.
    • are allergic to latex. The needle cap on the prefilled syringe contains dry natural rubber (derived from latex). You should not give NEUPOGEN® using the prefilled syringe if you have latex allergies. Ask your healthcare provider about using the vial if you have latex allergies.
    • are pregnant, or plan to become pregnant. It is not known if NEUPOGEN® will harm your unborn baby.
    • are breastfeeding, or plan to breastfeed. It is not known if NEUPOGEN® passes into your breast milk.

    Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

    How will I receive NEUPOGEN®?

    • NEUPOGEN® injections can be given by a healthcare provider by intravenous (IV) infusion or under your skin (subcutaneous injection). Your healthcare provider may decide subcutaneous injections can be given at home by you or your caregiver. If NEUPOGEN® is given at home, see the detailed "Instructions for Use" that comes with your NEUPOGEN® for information on how to prepare and inject a dose of NEUPOGEN®.
    • You and your caregiver should be shown how to prepare and inject NEUPOGEN® before you use it, by your healthcare provider.
    • Your healthcare provider will tell you how much NEUPOGEN® to inject and when to inject it. Do not change your dose or stop NEUPOGEN® unless your healthcare provider tells you to.
    • If you are receiving NEUPOGEN® because you are also receiving chemotherapy, your dose of NEUPOGEN® should be injected at least 24 hours before or 24 hours after your dose of chemotherapy.

    What are possible side effects of NEUPOGEN®?

    • Spleen rupture. Your spleen may become enlarged and can rupture. A ruptured spleen can cause death. Call your healthcare provider right away if you have pain in the left upper stomach area or left shoulder.
    • A serious lung problem called Acute Respiratory Distress Syndrome (ARDS). Call your healthcare provider or get emergency medical help right away if you have shortness of breath with or without a fever, trouble breathing, or a fast rate of breathing.
    • Serious allergic reactions. NEUPOGEN® can cause serious allergic reactions. These reactions can cause a rash over your whole body, shortness of breath, wheezing, dizziness, swelling around your mouth or eyes, fast heart rate, and sweating. If you have any of these symptoms, stop using NEUPOGEN®, and call your healthcare provider or get emergency help right away.
    • Sickle cell crises. You may have a serious sickle cell crisis if you have a sickle cell disorder and receive NEUPOGEN®. Serious sickle cell crises have happened in people with sickle cell disorders receiving NEUPOGEN® that has sometimes led to death. Call your healthcare provider right away if you have symptoms of sickle cell crisis such as pain or difficulty breathing.
    • Kidney injury (glomerulonephritis). NEUPOGEN® can cause kidney injury. Call your healthcare provider right away if you develop any of the following symptoms:
      • swelling of your face and ankles
      • blood in your urine or dark colored urine
      • you urinate less than usual
    • Capillary Leak Syndrome. NEUPOGEN® can cause fluid to leak from blood vessels into your body's tissues. This condition is called "Capillary Leak Syndrome" (CLS). CLS can quickly cause you to have symptoms that may become life-threatening. Get emergency medical help right away if you develop any of the following symptoms:
      • swelling or puffiness and are urinating less than usual
      • trouble breathing
      • swelling of your stomach-area and feeling of fullness
      • dizziness or feeling faint
      • a general feeling of tiredness
    • Decreased platelet count (thrombocytopenia). Your healthcare provider will check your blood during treatment with NEUPOGEN®. Tell your healthcare provider if you have unusual bleeding or bruising during treatment with NEUPOGEN®. This could be a sign of decreased platelet counts, which may reduce the ability of your blood to clot.
    • Increased white blood cell count (leukocytosis). Your healthcare provider will check your blood during treatment with NEUPOGEN®.
    • Inflammation of your blood vessels (cutaneous vasculitis). Tell your healthcare provider if you develop purple spots or redness of your skin.

    The most common side effects of NEUPOGEN® include aching in the bones and muscles. These are not all the possible side effect of NEUPOGEN®. Call your healthcare provider for medical advice about side effects. You may report side effects to FDA at 1-800-332-1088.

    Please see the NEUPOGEN® Patient Information for additional information.

  • Patients who are having their own blood cells collected
  • NEUPOGEN® is a prescription medicine used to collect immature white blood cells from your blood.

    Important Safety Information

    Do not take NEUPOGEN® if you have had a serious allergic reaction to human G-CSFs such as (filgrastim) or (pegfilgrastim) products.

    Before you take NEUPOGEN®, tell your healthcare provider all about your medical conditions, including if you:

    • have a sickle cell disorder.
    • have kidney problems.
    • are receiving radiation therapy.
    • are allergic to latex. The needle cap on the prefilled syringe contains dry natural rubber (derived from latex). You should not give NEUPOGEN® using the prefilled syringe if you have latex allergies. Ask your healthcare provider about using the vial if you have latex allergies.
    • are pregnant, or plan to become pregnant. It is not known if NEUPOGEN® will harm your unborn baby.
    • are breastfeeding, or plan to breastfeed. It is not known if NEUPOGEN® passes into your breast milk.

    Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

    How will I receive NEUPOGEN®?

    • NEUPOGEN® injections can be given by a healthcare provider by intravenous (IV) infusion or under your skin (subcutaneous injection). Your healthcare provider may decide subcutaneous injections can be given at home by you or your caregiver. If NEUPOGEN® is given at home, see the detailed "Instructions for Use" that comes with your NEUPOGEN® for information on how to prepare and inject a dose of NEUPOGEN®.
    • You and your caregiver should be shown how to prepare and inject NEUPOGEN® before you use it, by your healthcare provider.
    • Your healthcare provider will tell you how much NEUPOGEN® to inject and when to inject it. Do not change your dose or stop NEUPOGEN® unless your healthcare provider tells you to.
    • If you are receiving NEUPOGEN® because you are also receiving chemotherapy, your dose of NEUPOGEN® should be injected at least 24 hours before or 24 hours after your dose of chemotherapy.

    What are possible side effects of NEUPOGEN®?

    • Spleen rupture. Your spleen may become enlarged and can rupture. A ruptured spleen can cause death. Call your healthcare provider right away if you have pain in the left upper stomach area or left shoulder.
    • A serious lung problem called Acute Respiratory Distress Syndrome (ARDS). Call your healthcare provider or get emergency medical help right away if you have shortness of breath with or without a fever, trouble breathing, or a fast rate of breathing.
    • Serious allergic reactions. NEUPOGEN® can cause serious allergic reactions. These reactions can cause a rash over your whole body, shortness of breath, wheezing, dizziness, swelling around your mouth or eyes, fast heart rate, and sweating. If you have any of these symptoms, stop using NEUPOGEN®, and call your healthcare provider or get emergency help right away.
    • Sickle cell crises. You may have a serious sickle cell crisis if you have a sickle cell disorder and receive NEUPOGEN®. Serious sickle cell crises have happened in people with sickle cell disorders receiving NEUPOGEN® that has sometimes led to death. Call your healthcare provider right away if you have symptoms of sickle cell crisis such as pain or difficulty breathing.
    • Kidney injury (glomerulonephritis). NEUPOGEN® can cause kidney injury. Call your healthcare provider right away if you develop any of the following symptoms:
      • swelling of your face and ankles
      • blood in your urine or dark colored urine
      • you urinate less than usual
    • Capillary Leak Syndrome. NEUPOGEN® can cause fluid to leak from blood vessels into your body's tissues. This condition is called "Capillary Leak Syndrome" (CLS). CLS can quickly cause you to have symptoms that may become life-threatening. Get emergency medical help right away if you develop any of the following symptoms:
      • swelling or puffiness and are urinating less than usual
      • trouble breathing
      • swelling of your stomach-area and feeling of fullness
      • dizziness or feeling faint
      • a general feeling of tiredness
    • Decreased platelet count (thrombocytopenia). Your healthcare provider will check your blood during treatment with NEUPOGEN®. Tell your healthcare provider if you have unusual bleeding or bruising during treatment with NEUPOGEN®. This could be a sign of decreased platelet counts, which may reduce the ability of your blood to clot.
    • Increased white blood cell count (leukocytosis). Your healthcare provider will check your blood during treatment with NEUPOGEN®.
    • Inflammation of your blood vessels (cutaneous vasculitis). Tell your healthcare provider if you develop purple spots or redness of your skin.

    The most common side effects of NEUPOGEN® include aching in the bones and muscles. These are not all the possible side effect of NEUPOGEN®. Call your healthcare provider for medical advice about side effects. You may report side effects to FDA at 1-800-332-1088.

    Please see the NEUPOGEN® Patient Information for additional information.

  • Patients with severe chronic neutropenia (SCN)
  • NEUPOGEN® is a prescription medicine given long term to lower the number of times and duration of a low white blood cell count and its effects (eg fever, infections, mouth sores) in people who are born with conditions that may lead to a higher chance of experiencing symptoms from their low white blood cell count.

    Important Safety Information

    Do not take NEUPOGEN® if you have had a serious allergic reaction to human G-CSFs such as (filgrastim) or (pegfilgrastim) products.

    Before you take NEUPOGEN®, tell your healthcare provider all about your medical conditions, including if you:

    • have a sickle cell disorder.
    • have kidney problems.
    • are receiving radiation therapy.
    • are allergic to latex. The needle cap on the prefilled syringe contains dry natural rubber (derived from latex). You should not give NEUPOGEN® using the prefilled syringe if you have latex allergies. Ask your healthcare provider about using the vial if you have latex allergies.
    • are pregnant, or plan to become pregnant. It is not known if NEUPOGEN® will harm your unborn baby.
    • are breastfeeding, or plan to breastfeed. It is not known if NEUPOGEN® passes into your breast milk.

    Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

    How will I receive NEUPOGEN®?

    • NEUPOGEN® injections can be given by a healthcare provider by intravenous (IV) infusion or under your skin (subcutaneous injection). Your healthcare provider may decide subcutaneous injections can be given at home by you or your caregiver. If NEUPOGEN® is given at home, see the detailed "Instructions for Use" that comes with your NEUPOGEN® for information on how to prepare and inject a dose of NEUPOGEN®.
    • You and your caregiver should be shown how to prepare and inject NEUPOGEN® before you use it, by your healthcare provider.
    • Your healthcare provider will tell you how much NEUPOGEN® to inject and when to inject it. Do not change your dose or stop NEUPOGEN® unless your healthcare provider tells you to.
    • If you are receiving NEUPOGEN® because you are also receiving chemotherapy, your dose of NEUPOGEN® should be injected at least 24 hours before or 24 hours after your dose of chemotherapy.

    What are possible side effects of NEUPOGEN®?

    • Spleen rupture. Your spleen may become enlarged and can rupture. A ruptured spleen can cause death. Call your healthcare provider right away if you have pain in the left upper stomach area or left shoulder.
    • A serious lung problem called Acute Respiratory Distress Syndrome (ARDS). Call your healthcare provider or get emergency medical help right away if you have shortness of breath with or without a fever, trouble breathing, or a fast rate of breathing.
    • Serious allergic reactions. NEUPOGEN® can cause serious allergic reactions. These reactions can cause a rash over your whole body, shortness of breath, wheezing, dizziness, swelling around your mouth or eyes, fast heart rate, and sweating. If you have any of these symptoms, stop using NEUPOGEN®, and call your healthcare provider or get emergency help right away.
    • Sickle cell crises. You may have a serious sickle cell crisis if you have a sickle cell disorder and receive NEUPOGEN®. Serious sickle cell crises have happened in people with sickle cell disorders receiving NEUPOGEN® that has sometimes led to death. Call your healthcare provider right away if you have symptoms of sickle cell crisis such as pain or difficulty breathing.
    • Kidney injury (glomerulonephritis). NEUPOGEN® can cause kidney injury. Call your healthcare provider right away if you develop any of the following symptoms:
      • swelling of your face and ankles
      • blood in your urine or dark colored urine
      • you urinate less than usual
    • Capillary Leak Syndrome. NEUPOGEN® can cause fluid to leak from blood vessels into your body's tissues. This condition is called "Capillary Leak Syndrome" (CLS). CLS can quickly cause you to have symptoms that may become life-threatening. Get emergency medical help right away if you develop any of the following symptoms:
      • swelling or puffiness and are urinating less than usual
      • trouble breathing
      • swelling of your stomach-area and feeling of fullness
      • dizziness or feeling faint
      • a general feeling of tiredness
    • Decreased platelet count (thrombocytopenia). Your healthcare provider will check your blood during treatment with NEUPOGEN®. Tell your healthcare provider if you have unusual bleeding or bruising during treatment with NEUPOGEN®. This could be a sign of decreased platelet counts, which may reduce the ability of your blood to clot.
    • Increased white blood cell count (leukocytosis). Your healthcare provider will check your blood during treatment with NEUPOGEN®.
    • Inflammation of your blood vessels (cutaneous vasculitis). Tell your healthcare provider if you develop purple spots or redness of your skin.

    The most common side effects of NEUPOGEN® include aching in the bones and muscles. These are not all the possible side effect of NEUPOGEN®. Call your healthcare provider for medical advice about side effects. You may report side effects to FDA at 1-800-332-1088.

    Please see the NEUPOGEN® Patient Information for additional information.

See More See Less

Important Safety Information

Do not take NEUPOGEN® if you have had a serious allergic reaction to human G-CSFs such as (filgrastim) or (pegfilgrastim) products.

Before you take NEUPOGEN®, tell your healthcare provider all about your medical conditions, including if you:

  • have a sickle cell disorder.
  • have kidney problems.
  • are receiving radiation therapy.
  • are allergic to latex. The needle cap on the prefilled syringe contains dry natural rubber (derived from latex). You should not give NEUPOGEN® using the prefilled syringe if you have latex allergies. Ask your healthcare provider about using the vial if you have latex allergies.
  • are pregnant, or plan to become pregnant. It is not known if NEUPOGEN® will harm your unborn baby.
  • are breastfeeding, or plan to breastfeed. It is not known if NEUPOGEN® passes into your breast milk.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

How will I receive NEUPOGEN®?

  • NEUPOGEN® injections can be given by a healthcare provider by intravenous (IV) infusion or under your skin (subcutaneous injection). Your healthcare provider may decide subcutaneous injections can be given at home by you or your caregiver. If NEUPOGEN® is given at home, see the detailed "Instructions for Use" that comes with your NEUPOGEN® for information on how to prepare and inject a dose of NEUPOGEN®.
  • You and your caregiver should be shown how to prepare and inject NEUPOGEN® before you use it, by your healthcare provider.
  • Your healthcare provider will tell you how much NEUPOGEN® to inject and when to inject it. Do not change your dose or stop NEUPOGEN® unless your healthcare provider tells you to.
  • If you are receiving NEUPOGEN® because you are also receiving chemotherapy, your dose of NEUPOGEN® should be injected at least 24 hours before or 24 hours after your dose of chemotherapy.

What are possible side effects of NEUPOGEN®?

  • Spleen rupture. Your spleen may become enlarged and can rupture. A ruptured spleen can cause death. Call your healthcare provider right away if you have pain in the left upper stomach area or left shoulder.
  • A serious lung problem called Acute Respiratory Distress Syndrome (ARDS). Call your healthcare provider or get emergency medical help right away if you have shortness of breath with or without a fever, trouble breathing, or a fast rate of breathing.
  • Serious allergic reactions. NEUPOGEN® can cause serious allergic reactions. These reactions can cause a rash over your whole body, shortness of breath, wheezing, dizziness, swelling around your mouth or eyes, fast heart rate, and sweating. If you have any of these symptoms, stop using NEUPOGEN®, and call your healthcare provider or get emergency help right away.
  • Sickle cell crises. You may have a serious sickle cell crisis if you have a sickle cell disorder and receive NEUPOGEN®. Serious sickle cell crises have happened in people with sickle cell disorders receiving NEUPOGEN® that has sometimes led to death. Call your healthcare provider right away if you have symptoms of sickle cell crisis such as pain or difficulty breathing.
  • Kidney injury (glomerulonephritis). NEUPOGEN® can cause kidney injury. Call your healthcare provider right away if you develop any of the following symptoms:
    • swelling of your face and ankles
    • blood in your urine or dark colored urine
    • you urinate less than usual
  • Capillary Leak Syndrome. NEUPOGEN® can cause fluid to leak from blood vessels into your body's tissues. This condition is called "Capillary Leak Syndrome" (CLS). CLS can quickly cause you to have symptoms that may become life-threatening. Get emergency medical help right away if you develop any of the following symptoms:
    • swelling or puffiness and are urinating less than usual
    • trouble breathing
    • swelling of your stomach-area and feeling of fullness
    • dizziness or feeling faint
    • a general feeling of tiredness
  • Decreased platelet count (thrombocytopenia). Your healthcare provider will check your blood during treatment with NEUPOGEN®. Tell your healthcare provider if you have unusual bleeding or bruising during treatment with NEUPOGEN®. This could be a sign of decreased platelet counts, which may reduce the ability of your blood to clot.
  • Increased white blood cell count (leukocytosis). Your healthcare provider will check your blood during treatment with NEUPOGEN®.
  • Inflammation of your blood vessels (cutaneous vasculitis). Tell your healthcare provider if you develop purple spots or redness of your skin.

The most common side effects of NEUPOGEN® include aching in the bones and muscles. These are not all the possible side effect of NEUPOGEN®. Call your healthcare provider for medical advice about side effects. You may report side effects to FDA at 1-800-332-1088.

Please see the NEUPOGEN® Patient Information for additional information.

The last dose of NEUPOGEN® (filgrastim) should be injected at least 24 hours before your next dose of chemotherapy. NEUPOGEN® should be injected at the same time each day. If you miss a dose, contact your doctor or nurse.

You must always use the correct dose of NEUPOGEN®. Too little may not protect you against infections, and too much may cause too many neutrophils to be in your blood. If you are giving someone else NEUPOGEN® injections, it is important that you know how to inject, how much to inject, and how often to inject.

For more information, please see the NEUPOGEN® Patient Product Information and talk to your doctor.

No use NEUPOGEN® durante las 24 horas anteriores ni las 24 horas posteriores a la administración de quimioterapia fuerte. NEUPOGEN® debe inyectarse a la misma hora todos los días. Si se salta una dosis, póngase en contacto con el médico o el enfermero.

Es indispensable que use siempre la dosis correcta de NEUPOGEN®. Una cantidad insuficiente quizás no ayude a reducir el riesgo de contraer infecciones, y un exceso podría generar demasiados neutrófilos en la sangre. Si usted le administra las inyecciones de NEUPOGEN® a otra persona, es importante que sepa cómo inyectar el medicamento, las dosis que debe inyectar y con qué frecuencia debe poner las inyecciones.

Para obtener más información sobre cómo preparar y administrar una inyección de NEUPOGEN® consulte la información del producto para los pacientes y la información de prescripción de NEUPOGEN®. Si tiene preguntas, deberá hablar con su médico.